Reach Us +44 74-8287-4571
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Inflammatory Responses in Varicose Veins Surgery: Conventional Venous Stripping and Endovenous Radiofrequency Ablation (EV-RFA)

Background: Varicose veins surgery was evolved in the past decade. Many studies showed that endovenous ra-diofrequency ablation (EV-RFA), a novel method for varicose veins treatment, produced complications fewer than conventional venous stripping, particularly postoperative pain and ecchymosis. There were a lot of studies reported about inflammatory response but there were few studies compare inflammatory response between procedures. This study purpose compares preoperative and postoperative level of serum Interleukin 6 (IL-6) and C-reactive protein (CRP) to determine the inflammatory response of EV-RFA and conventional venous stripping. This study also compares visual analogue scale (VAS) and ecchymoses between these two procedures.

Methods: A prospective cohort study measuring IL-6 and CRP level at before and 24-hour after surgery in sympto-matic varicose vines patients who underwent either EV-RFA or conventional venous stripping.

Results: Fifty-nine patients were included, 27 patients were treated by conventional venous stripping and 32 pa-tients were treated by EV-RFA. There was no different in demographic characteristics among two groups. Twenty-four hour postoperative level of IL-6 and CRP significantly increased (p<0.001 and<0.001, respectively) in both EV-RFA group (p<0.001 and<0.001, respectively) and venous stripping group (p=0.043 and <0.001, respectively) com-pare to preoperative level. Increasing in 24 h postoperative level of IL-6 and CRP in EV-RFA group was significantly lower than in venous stripping group (p<0.001 and p=0.045, respectively). Postoperative VAS and ecchymosis were also significantly different between EV-RFA group and venous stripping group (p<0.001 and p<0.001, respectively).

Conclusions: EV-RFA produced inflammatory response, VAS and ecchymosis significantly lower than conventional venous stripping.


Nawaphan Taengsakul, Tanasit Saikaew, Norraporn Chaiaroon, Thatchawit Urasuk, Anucha Panoi, Thamrongroj Temudom and Pisake Boontham

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+

Upcoming Special Issues

Flyer image

Abstracted/Indexed in

  • Google Scholar
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs