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Venaseal In Varicose Veins-Histopathological Changes of Tissue and Veins

Zierau UT1*, Sell M2 and Lahl W1

1Founder and CEO of SAPHENION® - Surgeon, Vascular Surgeon, Phlebologist, Endovascular Specialist Artery, Endogenous Specialist Berlin/Rostock, Germany

2Department of Surgery, Massachusetts General Hospital, Boston

*Corresponding Author:
Zierau UT Founder and CEO of SAPHENION® - Surgeon, Vascular Surgeon, Phlebologist, Endovascular Specialist Artery Endogenous Specialist Berlin/Rostock, Germany Tel: 0491708302447 E-mail:[email protected]

Received date: August 07, 2019 Accepted date: September 09, 2019 Published date: September 16, 2019

Citation: Zierau UT, Sell M, Lahl W. Venaseal In Varicose Veins-Histopathological Changes of Tissue and Veins. J Vasc Endovasc Therapy 2019, Vol.4 No.3:18

Visit for more related articles at Journal of Vascular and Endovascular Therapy


Since 7 years we are working with VenaSeal (Medtronic, Minneapolis), a N-butyl-2 -cyanoacrylate in therapy of truncal varicose veins. Until to today time we treated 2350 truncal veins. The cyanoacrylat-polymer is a high effective vein glue for the treatment of patients with CVI and varicosie veins. As an implanted device, question is important: How long cyanoacrylate persists after using as a vein glue inside the truncal varicose veins.


VenaSeal; Cyanoacrylate vein glue; Foreign body reaction; Sealing truncal varicose veins


Sealing veins is a new therapy option since 2011 in Europe and since 2015 in USA. The technique of sealing wound, tissues, bones and vessels is not new yet, already since the earlier sixties we know sealing technique in dermatology. Since 1949 the chemical compound of cyanoacryle glue is known, first being used in operative medicine in the early 60s. All we know the tissue adhesive or replacement of wound sutures. Also the authors have used this glue during their time in trauma surgery in the 60th to 80th.

Today it´s real-nearly all operative disciplines are using cyanoacrylate, i.e., dermatology, ophthalmology, orthopedics, surgery, orthodontics, interventional radiology, vascular surgery, neurosurgery.

The risk of allergic reaction is not real-we didn`t found any real report or competent scientific study in medline or pubmed. And we ourself also didn`t seen any allergic reaction in using glue over all 7 years.

And also the FDA-approval states: VenaSeal® is bio-compatible/ resorptive, not carcinogenic and not allergenic!

Case Study

In 2017/2018 we saw three cases with a "glue pimple" (nearly 2 cm) above the treated and sealed varicose GSV. We thought, that these pimples were a direct reaction after sealing the veins. In one case the treatment with VenaSeal was 10 months ago, in 2 cases the therapy with the vein glue was 12 months ago After information the patient and getting the agreement, we have opened all the pimples with a scalpel, took a sharp spoon and peel ou all the whole content of the pimple including the pimple capsule. We sent all the material to a special institute for pathology.

Our question was: Is there any glue inside, are there any chemical adhesive residues? The next question was: Can we find any vein structures, can we see any competent vein wall?

The answer in all 3 cases was the same. You can read the result here:

Histopathology: Pathological-anatomical examination and assessment.

Microscopy: Thigh Inner left: Two 2 cm and 5 cm gray tissue fragments. Complete embedding.

Methods: Paraffin, HE, Elastica van Gieson staining, iron.

Microscopy: The tissue was completely embedded and shows histologically compactly stored polymorphonuclear granulocytes, fibrin, and fine narrow fiber structures. The Elastic van Gieson staining also shows individual fragmented elastic fibers. In the iron coloration no proof of pigment.

Assessment: Signs of inflammation with individual elastic fibers (left thigh), no malignancy: The elastic fibers could correspond to parts of a venous vessel, no foreign bodies (Figures 1 and 2).


Figure 1: Fibrin and some fresh blood as well as numerous granulocytes (HE staining).


Figure 2: Small fragments of split elastic fibers (brown colored) surrounded by granulocytes (EvG staining).

So the result was the same in all three cases: We can not find any vein wall, we can only find some elastic fibers as parts of the destroyed vein wall. We also can not find any rest of glue or other chemical compounds from the VenaSeal mixture (Figure 3).


Figure 3: Ultrasound examination 5 years after treatment with VenaSeal vein glue - also after this time we can not see an exact anatomical vein structure, also the moonlight shadow sign is not to be seen.


All we users of VenaSeal have one question: How long cyanoacrylate persists after closure? In our 3 cases the patients were examined 10 and 12 months after implantation of cyanoacrylate glue. Findings were typical of a foreign body reaction [1-7]. The vessel was occluded with collagenized mature fibrous tissue and polymer remnants, which were encapsulated by multinucleated giant cells. Focal areas of granulomatous inflammation were present in the destroyed vein wall parts extending to the surrounding tissue. This is the red skin streak, we can see in 8% of all treated veins. This is not a phlebitis o superficial vein thrombosis - this is the desribed inflamation after sealing the truncasl vein (Figure 4) [8,9].


Figure 4: Ultrasound examination of SSV left leg 7 years after sealing veins - there are no glue, no vein structure or other changes.

It were to be found also parts of elastic fibers of destroyed vein wall [1,2]. We have not found any thrombosis or thrombotic reaction inside a vein structure, no recanalisation. Also foreign material from the glue was not to be found after 10-12 months!

So we also havn`t seen-in contrast to Novotny (2)-any recanalisation of the obturated vein section (Figure 5) [10].


Figure 5: Ultrasound examination 7 years after VenaSeal ablation of GSV right leg: There is not to bee seen any vein anatomy or rest of glue or inflammatory residuals.

The results are similar all the animal tests since 1969. These tests described a chemical degradation of glue between 6 to 9 months in all animal tests. The faster reaction is justified in localisation of glue injection. Nearly all papers describe an injection in muscle tissue [8,11-16] this is tissue with better blood circulation then vein-or fat tissue.


N-butyl-2-cyanoacrylate that has been applied gradually degrades over the course of 10 months up to 3 years accompanied by a giant cell reaction, mild chronic inflammation and vein channel cicatrices.


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